Publications

The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage.

Jun S, Mahesula S, Mathews TP, Martin-Sandoval MS, Zhao Z, Piskounova E, Agathocleous M. Cell Metab. 2021 Aug 3:S1550-4131(21)00332-6. doi: 10.1016/j.cmet.2021.07.016

NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.

Schild T, McReynolds MR, Shea C, Low V, Schaffer BE, Asara JM, Piskounova E, Dephoure N, Rabinowitz JD, Gomes AP, Blenis J. Cell Rep. 2021 Jun 15;35(11):109238. doi: 10.1016/j.celrep.2021.109238.

The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro.

Yaron TM, Heaton BE, Levy TM, Johnson JL, Jordan TX, Cohen BM, Kerelsky A, Lin TY, Liberatore KM, Bulaon DK, Kastenhuber ER, Mercadante MN, Shobana-Ganesh K, He L, Schwartz RE, Chen S, Weinstein H, Elemento O, Piskounova E, Nilsson-Payant BE, Lee G, Trimarco JD, Burke KN, Hamele CE, Chaparian RR, Harding AT, Tata A, Zhu X, Tata PR, Smith CM, Possemato AP, Tkachev SL, Hornbeck PV, Beausoleil SA, Anand SK, Aguet F, Getz G, Davidson AD, Heesom K, Kavanagh-Williamson M, Matthews D, tenOever BR, Cantley LC, Blenis J, Heaton NS. bioRxiv. 2020 Dec 16:2020.08.14.251207. doi: 10.1101/2020.08.14.251207. Preprint.

An in vivo Kras allelic series reveals distinct phenotypes of common oncogenic variants.

Zafra MP, Parsons MJ, Kim J, Alonso-Curbelo D, Goswami S, Schatoff EM, Han T, Katti A, Fernandez MTC, Wilkinson JE, Piskounova E, Dow LE. Cancer Discov. 2020 Nov;10(11):1654-1671. doi: 10.1158/2159-8290.CD-20-0442. Epub 2020 Aug 12.

Ascorbate regulates hematopoietic stem cell function and leukaemogenesis.

Agathocleous M, Meacham CE, Burgess RJ, Piskounova E, Zhao Z, Crane GM, Cowin BL, Bruner E, Murphy MM, Chen W, Spangrude GJ, Hu Z, DeBerardinis RJ, Morrison SJ. Nature. 2017 Sep 28;549(7673):476-481. doi: 10.1038/nature23876. Epub 2017 Aug 21.

Cancer, Oxidative Stress, and Metastasis.

Gill JG, Piskounova E, Morrison SJ. Cold Spring Harb Symp Quant Biol. 2016; 81:163-175. doi: 10.1101/sqb.2016.81.030791. Epub 2017 Jan 12.

Oxidative stress inhibits distant metastasis by human melanoma cells.

Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ. Nature. 2015 Nov 12;527(7577):186-91. doi: 10.1038/nature15726. Epub 2015 Oct 14.

Human melanoma metastasis in NSG mice correlates with clinical outcome in patients.

Quintana E, Piskounova E, Shackleton M, Weinberg D, Eskiocak U, Fullen DR, Johnson TM, Morrison SJ. Sci Transl Med. 2012 Nov 7;4(159):159ra149. doi: 10.1126/scitranslmed.3004599.

Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty.

Silveira-Neto AP, Leal LF, Emerman AB, Henderson KD, Piskounova E, Henderson BE, Gregory RI, Silveira LF, Hirschhorn JN, Nguyen TT, Beneduzzi D, Tusset C, Reis AC, Brito VN, Mendonca BB, Palmert MR, Antonini SR, Latronico AC. Horm Res Paediatr. 2012;78(3):144-50. doi: 10.1159/000342212. Epub 2012 Sep 6.

Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TuT7).

Thornton JE, Chang HM, Piskounova E, Gregory RI. RNA. 2012 Oct;18(10):1875-85. doi: 10.1261/rna.034538.112. Epub 2012 Aug 16.

Cancer stem cells: impact, heterogeneity, and uncertainty.

Magee JA, Piskounova E, Morrison SJ. Cancer Cell. 2012 Mar 20;21(3):283-96. doi: 10.1016/j.ccr.2012.03.003.

Lin28A and Lin 28B inhibit let-7 microRNA biogenesis by distinct mechanisms.

Piskounova E, Polytarchou C, Thornton JE, LaPierre RJ, Pothoulakis C, Hagan JP, Iliopoulos D, Gregory RI. Cell. 2011 Nov 23;147(5):1066-79. doi: 10.1016/j.cell.2011.10.039.

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells.

Hagan JP, Piskounova E, Gregory RI. Nat Struct Mol Biol. 2009 Oct;16(10):1021-5. doi: 10.1038/nsmb.1676. Epub 2009 Aug 27.

Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.

Piskounova E, Viswanathan SR, Janas M, LaPierre RJ, Daley GQ, Sliz P, Gregory RI. J Biol Chem. 2008 Aug 1;283(31):21310-4. doi: 10.1074/jbc.C800108200. Epub 2008 Jun 12.