The Piskounova Lab
Stress adaptation and translational control in cancer metastasis
We study how metastatic cancer cells survive oxidative, metabolic, and microenvironmental stress, and how those adaptive pathways can be targeted therapeutically.
Areas of Research
Metabolic Adaptation
What are the metabolic adaptations that enable survival and colonization of vital organs by metastasizing cancer cells?
Mechanisms of Stress resistance
Metastasis is a stressful multi-step process. What mechanisms of stress resistance are metastasizing cells most dependent on at different steps of the metastatic cascade?
Molecular plasticity
Metastasizing cells display increased degree of molecular plasticity. How is this achieved? What are the main regulatory hubs of plasticity that can be harnessed therapeutically?
Located in Boston's Longwood Medical Area:
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The Piskounova Lab is part of the Cancer Research Institute at Beth Israel Deaconess Medical Center, a major teaching hospital of Harvard Medical School. Located in Boston's renowned Longwood Medical Area, BIDMC is surrounded by world-class research institutions including Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Boston Children's Hospital.
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Dana-Farber Cancer Institute
Brigham and Women's Hospital
Boston Children's Hospital
Harvard Medical School
Harvard School of Public Health
Joslin Diabetes Center
“Any scientist of any age who wants to make important discoveries must study important problems. Dull or piffling problems yield dull or piffling answers. It is not enough that a problem should be “interesting.” … The problem must be such that it matters what the answer is—whether to science generally or to mankind.”